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Effects of Iron Supplementation on Pediatric Vaccine Response

NCT04744818 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 288

Last updated 2024-01-24

No results posted yet for this study

Summary

ID/IDA affects many young children in Africa. Vaccines provide tremendous benefits in LMIC; however, they currently fail to reach their full potential. We need to better understand the causes of vaccine failure, in order to develop new strategies to improve vaccine immunogenicity.

This study will contribute to children's health by: (1) providing updated guidelines to better define the prevalence of ID/IDA in early infancy, and its safe and effective control using iron; and (2) providing a new approach to improve response to pediatric vaccines in LMIC, by ensuring adequate iron status at time of vaccination.

Conditions

Interventions

DIETARY_SUPPLEMENT

Iron syrup

Daily supplementation with iron

DIETARY_SUPPLEMENT

Multivitamin syrup

Daily supplementation with multivitamins

Sponsors & Collaborators

  • Jomo Kenyatta University of Agriculture and Technology Kenya

    collaborator UNKNOWN

  • Karolinka Institute Sweden

    collaborator UNKNOWN

  • University of Oxford

    collaborator OTHER

  • National Institute for Public Health and Environment Netherlands

    collaborator UNKNOWN

  • Jessica Rigutto

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
39 Days
Max Age
45 Days
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-02-07
Primary Completion
2023-04-03
Completion
2023-10-16

Countries

  • Kenya
  • Switzerland

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04744818 on ClinicalTrials.gov