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Individualizing tDCS Dose

NCT04742439 · Status: WITHDRAWN · Phase: NA · Type: INTERVENTIONAL

Last updated 2025-11-06

No results posted yet for this study

Summary

Transcranial direct current stimulation (tDCS) is a noninvasive method of modulating brain activity and has therapeutic potential in many neurological and psychiatric conditions. However, unlike every current FDA-approved form of brain stimulation, there is no method of individualizing stimulation dose. In this study, a method of individualizing tDCS dose on behavioral outcomes and whether this could help to improve the consistency and magnitude of the stimulation effects will be tested.

Conditions

  • tDCS
  • Motor Function

Interventions

DEVICE

Sham transcranial direct current stimulation

Participants will receive 30 seconds of ramp up and down stimulation at the start and end of the 20 minute stimulation period.

DEVICE

Individualized transcranial direct current stimulation

Participants will receive 20 minutes of transcranial direct current stimulation (tDCS) at the individualized dose (maximum of 4mA).

DEVICE

2mA transcranial direct current stimulation

Participants will receive 20 minutes of transcranial direct current stimulation (tDCS) at a 2mA dose.

DEVICE

4mA transcranial direct current stimulation

Participants will receive 20 minutes of transcranial direct current stimulation (tDCS) at a 4mA dose.

Sponsors & Collaborators

  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

    collaborator NIH

  • Medical University of South Carolina

    lead OTHER

Principal Investigators

  • Mark S George, MD · Medical University of South Carolina

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-12-02
Primary Completion
2024-12-02
Completion
2024-12-02
FDA Device
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04742439 on ClinicalTrials.gov