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An Exploratory Clinical Study on Autophagy During Fasting

NCT04739852 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2024-01-02

No results posted yet for this study

Summary

Autophagy is considered one of the key molecular mechanisms for the broad preventive and therapeutic effects of periodic fasting. While it is generally known that fasting induces autophagy, there are no human studies that focus on the size and temporal kinetics of autophagy and its association with fasting specific signaling pathways. The kinetics of autophagy in patients with chronic diseases will now be compared with the kinetics of autophagy in healthy subjects, who both fast according to the same scheme; and further changes in metabolic and inflammatory parameters will be investigated.

Conditions

  • Arthritis, Rheumatoid
  • Syndrome, Metabolic
  • Healthy

Interventions

OTHER

Fasting

Patients undergo a 5-10 day fasting period with a dietary energy supply 350-400kcal per day with fruit and vegetable juices or, if not feasible, an established fasting-mimicking diet of 600-800 kcal according to Longo et al.

Sponsors & Collaborators

  • Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Bonn AöR

    collaborator UNKNOWN

  • Charite University, Berlin, Germany

    lead OTHER

Principal Investigators

  • Andreas Michalsen, Prof. Dr. · Charite - Universitätsmedizin Berlin

  • Nils Gassen, Dr. · Department of Psychiatry and Psychotherapy University Bonn, Clinical Centre

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-02-01
Primary Completion
2025-02-01
Completion
2025-07-01

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04739852 on ClinicalTrials.gov