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Effect of Postprandial Hyperglycemia on Vasculature in Type 1 Diabetes and Healthy Adults

NCT04730882 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 36

Last updated 2025-03-30

No results posted yet for this study

Summary

To the investigator's knowledge, there are no data available in the current literature regarding the acute effects of postprandial hyperglycemia and insulin timing on myocardial perfusion in people with type 1 diabetes (T1D). Observational studies using CEU in type 2 diabetes demonstrate that postprandial hyperglycemia determines myocardial perfusion defects. The investigator hypothesizes that the combination of postprandial hyperglycemia and insulin increases pulse wave velocity (i.e., aortic stiffness) and myocardial vasoconstriction, thereby reducing myocardial perfusion in T1D when compared to healthy controls. Furthermore, the investigator hypothesizes in T1D that dosing insulin before meal intake will ameliorate these cardiovascular defects.

Conditions

Interventions

DIETARY_SUPPLEMENT

Mixed Meal

the meal will be 40% of each subject's daily estimated caloric need, with 50%, 30%, 20% from carbohydrates, fat and protein, respectively

Sponsors & Collaborators

  • National Center for Advancing Translational Sciences (NCATS)

    collaborator NIH

  • University of Virginia

    lead OTHER

Principal Investigators

  • William Horton, MD · University of Virginia, Department of Endocrinology

  • Zhenqi Liu, MD · University of Virginia, Department of Endocrinology

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-04-06
Primary Completion
2024-10-18
Completion
2024-10-18

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04730882 on ClinicalTrials.gov