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Identification of New Markers of Atrial Myopathy in Patients With Embolic Stroke of Undetermined Source (ESUS) From MRI 4D Data

NCT04717843 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2023-09-21

No results posted yet for this study

Summary

Atrial myopathy is considered to be the underlying cause of a large proportion of embolic strokes of undetermined source. However, the definition of this atrial condition is not well delineated while its identification could lead to prescription on anticoagulation in order to avoid stroke recurences. This study aims to identify new markers of atrial myopathy and choosed a multi parametric approach with electrical, echographical, biological and 4D flow CMR derived markers.

Conditions

  • Embolic Stroke of Undetermined Source

Interventions

OTHER

4D Flow MRI

Acquisitions of MR imagining with special contrast phase CMR sequences. There is no need for agent contrast injection. The CMR is performed at the time of inclusion.

OTHER

Medical consultation with 12 leads ECG

Collection of medical history, treatment, physical examination and realization of a 12 leads ECG.

OTHER

Holter ECG

48 hours ECG recording

OTHER

Trans thoracic echocardiography

Trans thoracic echocardiography with standard measures performes in the core lab.

BIOLOGICAL

Blood sample

Blood sample in a peripheral vein, send to medical laboratory to dosage of NT pro BNP and troponin serum level.

OTHER

Standard MRI

Acquisitions of MR imagining

Sponsors & Collaborators

  • Hospices Civils de Lyon

    lead OTHER

Principal Investigators

  • Philippe CHEVALIER, Pr · Chief of the Arrhythmia Unit at the Academic Hospital of Lyon

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-03-01
Primary Completion
2024-09-01
Completion
2024-09-01

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04717843 on ClinicalTrials.gov