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Bone Density and Vascular Calcifications Evolution After Renal Transplant

NCT04713774 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2024-12-18

No results posted yet for this study

Summary

The investigators project is based on:

* Assessment of bone architecture by high resolution peripheral scanner (HRpQCT) and bone densitometry (DEXA);
* The non-invasive detection of vascular calcifications (by abdominal CT scanner) and bone abnormalities associated with kidney transplantation, as well as the analysis of evolution over time;
* Longitudinal evaluation of nephrological clinical parameters (glomerular filtration rate, number and type of rejections, immunosuppressive medications) as well as biological and urinary parameters of mineral metabolism (parathormone, sclerostin, bone alkaline phosphatase) depending on the type and severity of bone abnormalities;
* The evaluation of these nephrological clinical parameters and of the biological parameters of mineral metabolism depending on the extent and evolution of vascular calcifications but also on bone morphology;
* The study of possible relationships between bone mass and muscle mass (and functioning)

Conditions

  • Kidney Transplant; Complications
  • Bone Loss

Interventions

DEVICE

High-resolution peripheral quantitative CT scanner (HRpQCT)

HR-pQCT images of the distal radius and distal tibia (non-dominant, non-fractured limb) will be obtained using the XtremeCT device with standard protocols. HR-pQCT images wil be analysed with standard software and extended cortical measures software. This software identifies the periosteal and endosteal boundaries, enabling assessment of cortical micro- structural bone properties, including apparent cortical thickness (Ct.Th, mm), cortical tissue mineral density (TMD, mgHA/cm3) and cortical porosity (Ct.Po, %).

Sponsors & Collaborators

  • University of Liege

    lead OTHER

Principal Investigators

  • Antoine Bouquegneau · University of Liege

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-09-01
Primary Completion
2025-12-12
Completion
2026-12-13

Countries

  • Belgium

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04713774 on ClinicalTrials.gov