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Nitrate and Brain Insulin-Sensitivity

NCT04700241 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 18

Last updated 2021-06-09

No results posted yet for this study

Summary

Disturbances in brain insulin-sensitivity are not only observed in abdominal obesity and type 2 diabetes mellitus (T2D), but also during brain aging and in dementia. Inorganic nitrate may improve brain insulin-sensitivity, which can be quantified by measuring the gray-matter cerebral blood flow (CBF) response to intranasally administered insulin, through beneficial effects on brain vascular function. Therefore, we now hypothesize that inorganic nitrate, which can be found in several vegetables such as beetroot, improves brain insulin-sensitivity, as assessed by the gray-matter CBF response to intranasally administered insulin, in abdominally obese men.

Conditions

  • Nitrate
  • Brain Insulin-sensitivity
  • Vascular Function

Interventions

DIETARY_SUPPLEMENT

Potassium nitrate

Acute intervention (5.5 hours)

DIETARY_SUPPLEMENT

Placebo

Acute intervention (5.5 hours)

Sponsors & Collaborators

  • Maastricht University Medical Center

    lead OTHER

Principal Investigators

  • Peter J. Joris, Dr · Maastricht University

  • Ronald P.M. Mensink, Dr · Maastricht University

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-01-21
Primary Completion
2021-05-05
Completion
2021-05-05

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04700241 on ClinicalTrials.gov