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The Acute Respiratory Intervention StudiEs in Africa (ARISE-AFRICA) Study

NCT04693403 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 705

Last updated 2025-08-14

No results posted yet for this study

Summary

The dearth of Intensive care units in low resource settings portends for poor outcomes amongst patients with acute hypoxemic respiratory failure (AHRF) . To our knowledge, the effect of CPAP and HFNC on major outcomes has not been assessed in adults with AHRF in resource-limited settings. The aim of this prospective, multicenter, randomized, controlled, trial is to determine whether High-flow oxygen through a nasal cannula (HFNC) or Continuous positive airway pressure (CPAP) system can reduce mortality among patients with acute hypoxemic respiratory failure (AHRF) in a limited resource setting as compared with standard low flow oxygen therapy?

Conditions

  • Acute Respiratory Failure With Hypoxia
  • Acute Respiratory Distress Syndrome
  • Acute Lung Injury

Interventions

PROCEDURE

HFNC

40-60l/min humidified oxygen by nasal cannula

PROCEDURE

CPAP

Oxygen therapy by boussignac Continuous positive airway pressure face mask

PROCEDURE

Standard Oxygen

Oxygen therapy by low flow (upto 15l/min) by Non-rebreather face mask

Sponsors & Collaborators

  • THRiVE

    collaborator UNKNOWN

  • Paris 12 Val de Marne University

    collaborator OTHER

  • Wellcome Trust

    collaborator OTHER

  • Makerere University

    lead OTHER

Principal Investigators

  • Arthur Kwizera, MD · Makerere University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
95 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-03-13
Primary Completion
2024-01-15
Completion
2024-03-31

Countries

  • Uganda

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04693403 on ClinicalTrials.gov