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Serial FES PET/CT to Measure Hormone Expression in Patients Undergoing Endocrine Targeted Therapy

NCT04692103 · Status: ACTIVE_NOT_RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 2

Last updated 2026-01-22

Study results available
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Summary

This clinical trial studies use of F-18 16 alpha-fluoroestradiol (\[F-18\] FES) positron emission tomography (PET)/computed tomography (CT) in measuring tumor hormone receptor expression in patients undergoing endocrine-targeted therapy for newly diagnosed breast cancer or breast cancer that has come back or spread to other places in the body. Comparing results of diagnostic procedures done before, during, and after hormone therapy may help measure a patient's response to treatment.

Conditions

  • Estrogen Receptor Positive
  • Primary or Recurrent Breast Carcinoma
  • Stage IV Breast Cancer AJCC v6 and v7

Interventions

DRUG

F-18 16 Alpha-Fluoroestradiol

Undergo F-18 FES PET/CT

PROCEDURE

Positron Emission Tomography

Undergo F-18 FES PET/CT

PROCEDURE

Computed Tomography

Undergo F-18 FES PET/CT

DRUG

Fludeoxyglucose F-18

Undergo FDG PET/CT

PROCEDURE

Positron Emission Tomography

Undergo FDG PET/CT

PROCEDURE

Computed Tomography

Undergo FDG PET/CT

OTHER

Laboratory Biomarker Analysis

Correlative studies

Sponsors & Collaborators

Principal Investigators

  • Hannah Linden · Fred Hutch/University of Washington Cancer Consortium

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-07-10
Primary Completion
2021-10-01
Completion
2041-04-30
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04692103 on ClinicalTrials.gov