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Non-invasive Characterization of Systemic Microvascular Reactivity by Near-infrared Diffuse Optical Spectroscopy in COVID-19 Patients

NCT04689477 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 612

Last updated 2022-08-01

No results posted yet for this study

Summary

The purpose of this study is to characterize microvascular reactivity on the forearm muscle using non-invasive near-infrared spectroscopy in critically ill COVID-19 patients, and to correlate its alterations with 28-day mortality in ICU COVID-19 patients.

Conditions

Interventions

DEVICE

Vascular occlusion test

The ischemic challenge will consist in a standardized Vascular Occlusion Test (VOT), as previously described in the literature. Briefly, a blood pressure cuff will be placed proximal to the forearm, and rapidly inflated at 40 mmHg above systolic pressure, and kept inflated during three minutes. Then the cuff will be rapidly deflated. The resulting deoxygenation (DeO2) and reoxygenation (ReO2) slopes will be reported as change in O2 saturation over time.

Sponsors & Collaborators

  • Institut de Ciències Fotòniques (ICFO)

    collaborator UNKNOWN

  • Centre de Recerca Matemàtica

    collaborator UNKNOWN

  • Institute of Physics University of Campinas

    collaborator UNKNOWN

  • Corporacion Parc Tauli

    lead OTHER

Principal Investigators

  • Jaume Mesquida, MD, PhD · Corporacion Parc Tauli

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-05-25
Primary Completion
2022-10-31
Completion
2022-10-31
FDA Device
Yes

Countries

  • United States
  • Brazil
  • Mexico
  • Spain

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04689477 on ClinicalTrials.gov