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Functional Lung Avoidance SPECT-guided Radiation Therapy of Lung Cancer

NCT04676828 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 90

Last updated 2026-02-24

No results posted yet for this study

Summary

Study aims to determine if functional lung avoidance based on perfusion single photon emission (SPECT)/CT scan, improves toxicity outcomes for patients with advanced lung cancer undergoing chemo-radiotherapy. Functional avoidance implies a dose plan that takes functional distribution in the lung into account, and avoids highly functional lung volumes sparing them from radiation.

Conditions

  • Lung Cancer
  • Radiation-Induced Disorder
  • Radiation Pneumonitis
  • Pulmonary Disease
  • Lung Function Decreased

Interventions

DIAGNOSTIC_TEST

Single-photon-emission CT scan

SPECT/CT scan is an established functional modality used in the diagnosis and monitoring of lung disease. SPECT/CT scan images pulmonary circulation, where perfused areas equate with normal functional lung

Sponsors & Collaborators

  • Westmead and Blacktown Hospital, Sydney West Radiation Oncology Network, Sydney, Australia

    collaborator UNKNOWN

  • Aarhus University Hospital

    collaborator OTHER

  • South Eastern Sydney Local Health District

    collaborator OTHER_GOV

  • The University of New South Wales

    collaborator OTHER

  • Northern NSW Local Health District, NSW Australia

    collaborator UNKNOWN

  • University of Aarhus

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-12-01
Primary Completion
2027-12-01
Completion
2028-12-01

Countries

  • Australia
  • Denmark

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04676828 on ClinicalTrials.gov