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The Impact of Air Pollution on the Consumption of Antimicrobials in the General Population

NCT04662047 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 3249128

Last updated 2023-01-25

No results posted yet for this study

Summary

Objectives: To test the hypothesis that certain levels of air pollution may lead to increases in 1) antimicrobial consumption in the general population and 2) the presence of antibiotic resistance genes.

Methods: The project will consist of two sub-studies:

1. A time series analysis of the association between daily antimicrobial consumption and air pollution in the 11 largest cities in Catalonia (2006-2022). Outcome variable: daily consumption of antimicrobials. Independent variables: air pollution and confounding variables. The analysis will use generalized additive models: through a random effects meta-analysis, the concentration-response estimates for each city will be added together to calculate the overall estimates.
2. Descriptive observational study of the relationship between the concentration of resistance genes and antimicrobial consumption in the Barcelona area (2021-2023).

Outcome variable: concentration of antibiotic resistance genes. Independent variables: defined daily dose of antimicrobials per 1000 inhabitants-day. Descriptive analysis of the concentration and diversity of antibiotic resistance genes according to air quality monitoring station (urban vs. hospital environment), month, and correlation with antimicrobial consumption.

Conditions

  • Community-acquired Pneumonia
  • Air Pollution
  • Drug Resistance, Microbial

Sponsors & Collaborators

  • Public Health Agency of Barcelona

    collaborator OTHER

  • Hospital Clinic of Barcelona

    collaborator OTHER

  • Carlos III Health Institute

    collaborator OTHER_GOV

  • Hospital Universitari de Bellvitge

    lead OTHER

Principal Investigators

  • Marc Marí-Dell'Olmo, PhD · Public Health Barcelona Agency

  • Ariadna Padullés, PhD · Bellvitge University Hospital

  • Adriana Vergara, PhD · Clinic University Hospital

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-01-01
Primary Completion
2023-12-31
Completion
2023-12-31

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04662047 on ClinicalTrials.gov