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RACE-CARS - RAndomized Cluster Evaluation of Cardiac ARrest Systems

NCT04660526 · Status: ENROLLING_BY_INVITATION · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20000

Last updated 2026-05-06

No results posted yet for this study

Summary

RACE-CARS is a real-world cluster-randomized trial designed to evaluate a multifaceted community and health systems intervention aimed to improve outcomes of out-of-hospital cardiac arrest. RACE-CARS will enroll 50 counties in North Carolina that are estimated to have a total of approximately 20,000 patients with cardiac arrest over a 4-year intervention period. County "clusters" will be randomized in a 1:1 ratio to intervention versus usual care. The trial duration is 7 years, which includes a 6-month start-up (including recruitment and randomization) period, a 12-month intervention training phase, a 4-year intervention period, a 12-month follow-up for to assess quality of life in survivors of OHCA, and a 6-month close-out and data analysis period.

Conditions

  • Cardiac Arrest

Interventions

OTHER

Rapid cardiac arrest recognition that triggers immediate priority EMS/first responder dispatch by 911 operators

EMS first responders will recognize cardiac arrest and respond immediately, increasing time to dispatch

OTHER

Systematic bystander resuscitation instruction by 911 operators

911 operators will be able to describe how to administer CPR over the phone.

OTHER

Comprehensive community training of lay people in CPR and AED use.

Training of lay people regarding CPR and AED use.

OTHER

Optimized first responder performance including earlier use of AEDs.

First responders will recognize where AEDs are located and use them appropriately

Sponsors & Collaborators

  • National Heart, Lung, and Blood Institute (NHLBI)

    collaborator NIH

  • Duke University

    lead OTHER

Principal Investigators

  • Christopher Granger, MD · Duke University

Study Design

Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-07-01
Primary Completion
2026-06-30
Completion
2027-06-30

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04660526 on ClinicalTrials.gov