MedTrace Logo

Suspicion of Non IgE-mediated Cow's Milk Protein Allergy: Prevalence and Evolution

NCT04651829 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2020-12-03

No results posted yet for this study

Summary

Cow's milk protein allergy (CMPA) is often evoked in infants, in particular in front of delayed symptoms such as rectal bleeding, atopic dermatitis, excessive crying, reflux, failure to thrive... But in case of non IgE-mediated CMPA, the only way to diagnose this allergy is to proceed to an elimination-reintroduction test over a period of 2 to 4 weeks, to improve symptoms first, and then provoke them. Even if the diagnosis is confirmed, we speculate that non IgE-mediated CMPA has a faster resolution than other CMPA.

The first aim of this study is to estimate the prevalence of non IgE-mediated CMPA in a cohort of infants with delayed symptoms which could be relied to a CMPA. The second goal is evaluate the age of tolerance in non IgE-mediated CMPA with oral food challenge for milk ever 2 months after 4 months of age.

Conditions

  • Food Allergy in Infants
  • Proctocolitis
  • Atopic Dermatitis
  • Reflux, Gastroesophageal
  • Tolerance

Interventions

OTHER

oral food challenge 1

First oral food challenge after a short period of several weeks of avoidance of CMP to confirm diagnosis of CMPA

OTHER

oral food challenge 2

Second oral food challenge to test tolerance after 4 months of age if confirmed CMPA

Sponsors & Collaborators

  • Hôpital Armand Trousseau

    lead OTHER

Eligibility

Max Age
4 Months
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-05-31
Primary Completion
2014-05-31
Completion
2017-12-31

Countries

  • France

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04651829 on ClinicalTrials.gov