A Study to Evaluate the Safety and Tolerability of RO7296682 in Combination With Atezolizumab in Participants With Advanced Solid Tumors.
NCT04642365 · Status: TERMINATED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 49
Last updated 2025-05-21
Summary
This study will evaluate the safety, tolerability and preliminary anti-tumor activity of RO7296682 in combination with Atezolizumab in participants with advanced solid tumors.
Conditions
Interventions
- DRUG
-
RO7296682
RO7296682 will be administered as per the schedules specified in the respective arms.
- DRUG
-
Atezolizumab will be administered as per the schedules specified in the respective arms.
Sponsors & Collaborators
- lead INDUSTRY
Principal Investigators
-
Clinical Trials · Hoffmann-La Roche
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SEQUENTIAL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2021-01-04
- Primary Completion
- 2024-01-04
- Completion
- 2024-01-04
- FDA Drug
- Yes
Countries
- United States
- Australia
- Belgium
- Canada
- Denmark
- Spain
Study Locations
More Related Trials
-
A Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of TT125-802 in Subjects With Advanced Solid Tumors
NCT06403436 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
A Study to Assess the Safety and Pharmacokinetics of MOXR0916 and Atezolizumab (Also Known as MPDL3280A or Anti-PD-L1) in Participants With Locally Advanced or Metastatic Solid Tumors
NCT02410512 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of AZD0466 in Patients With Advanced Hematologic or Solid Tumors
NCT04214093 ·Status: TERMINATED ·Phase: PHASE1
-
A Study of Selicrelumab (RO7009789) in Combination With Atezolizumab in Participants With Locally Advanced and/or Metastatic Solid Tumors
NCT02304393 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of Enzelkitug as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors
NCT05581004 ·Status: RECRUITING ·Phase: PHASE1
-
Study of Atezolizumab in Combination With Cobimetinib in Participants With Locally Advanced or Metastatic Solid Tumors
NCT01988896 ·Status: COMPLETED ·Phase: PHASE1
-
A Study in Patients Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab Study
NCT03768063 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Preliminary Clinical Activity of RO7673396 in Participants With Advanced Solid Tumors Harboring Rat Sarcoma Viral Oncogene Homolog (RAS) Mutation(s)
NCT06884618 ·Status: RECRUITING ·Phase: PHASE1
-
A Phase 1 Study of RO7623066 Alone and in Combination in Patients With Advanced Solid Tumors
NCT05240898 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of RO7172508 in Patients With Locally Advanced and/or Metastatic CEA-Positive Solid Tumors
NCT03539484 ·Status: TERMINATED ·Phase: PHASE1
-
A Phase I, Open-Label, Multi-center Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD6244 (ARRY-142886)
NCT00600496 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
An Open-Label Dose-Escalation Study to Evaluate XmAb24306 as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors
NCT04250155 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
A Study of Emactuzumab and RO7009789 Administered in Combination in Participants With Advanced Solid Tumors
NCT02760797 ·Status: COMPLETED ·Phase: PHASE1
-
Safety and Efficacy of SB 11285 Alone and in Combination With Atezolizumab in Patients With Advanced Solid Tumors
NCT04096638 ·Status: COMPLETED ·Phase: PHASE1
-
A Study Exploring the Safety and Tolerability of INCB081776 in Participants With Advanced Malignancies
NCT03522142 ·Status: TERMINATED ·Phase: PHASE1
-
A Study of Vanucizumab (RO5520985) Alone or in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors
NCT01688206 ·Status: COMPLETED ·Phase: PHASE1
-
AZD6244 (ARRY-142886) Solid Oral Dosage Formulation in Participants With Advanced Solid Malignancies
NCT00463814 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Study of E7046 in Subjects With Selected Advanced Malignancies
NCT02540291 ·Status: TERMINATED ·Phase: PHASE1
-
A Study Evaluating The Safety And Pharmacokinetics Of Escalating Doses Of RO7297089 In Patients With Relapsed Or Refractory Multiple Myeloma
NCT04434469 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of the Safety and Efficacy of Atezolizumab Administered in Combination With Bevacizumab and/or Other Treatments in Participants With Solid Tumors
NCT02715531 ·Status: COMPLETED ·Phase: PHASE1
-
Study of Atezolizumab as Monotherapy and in Combination With Platinum-Based Chemotherapy in Participants With Untreated Locally Advanced or Metastatic Urothelial Carcinoma
NCT02807636 ·Status: COMPLETED ·Phase: PHASE3
-
A Study of Atezolizumab in Locally Advanced or Metastatic Urothelial or Non-Urothelial Carcinoma of the Urinary Tract
NCT02928406 ·Status: COMPLETED ·Phase: PHASE3
-
Phase 1-2 Study of ASTX660 in Subjects With Advanced Solid Tumors and Lymphomas
NCT02503423 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies
NCT04644068 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
First in Human Study to Evaluate the Safety, Tolerability of HH30134 in Advanced Solid Tumors
NCT04746612 ·Status: TERMINATED ·Phase: PHASE1