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Assessing Neuroinflammation in GWI Using MRS

NCT04638998 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 49

Last updated 2025-01-13

Study results available
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Summary

The primary aim of this study is to determine if Gulf War Illness (GWI) likely involves neuroinflammation. The investigators hypothesize that GWI involves neuroinflammation. By assessing the five neuroinflammatory outcomes across the brain, the investigators can determine if there are focal or global signs of one or more neuroinflammatory markers in the brains of individuals with GWI. This neuroimaging technique may allow investigators and others to detect cases of GWI neuroinflammation, which would improve treatment decisions as well as the development of new targeted therapies. It is an ideal diagnostic tool because it has low patient risk, is noninvasive, can be used repeatedly in longitudinal studies, provides whole-brain coverage, yields multiple independent markers of inflammation, and can be employed at most hospitals and research neuroimaging suites.

Conditions

  • Gulf War Syndrome

Interventions

PROCEDURE

Magnetic Resonance Spectroscopic Imaging

MRSI is a non invasive imaging technique used to detect neuroinflammation.

PROCEDURE

Blood draw

Blood will be drawn to assess systemic inflammation in Gulf War verterans.

Sponsors & Collaborators

  • United States Department of Defense

    collaborator FED

  • University of Alabama at Birmingham

    lead OTHER

Principal Investigators

  • Jarred Younger, PhD · University of Alabama at Birmingham

Eligibility

Min Age
46 Years
Max Age
70 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-12-01
Primary Completion
2023-09-29
Completion
2023-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04638998 on ClinicalTrials.gov