Physical Capacity in Hodgkin Lymphoma Survivors

Summary

The study aims to investigate if physical capacity obtained in the cardiopulmonary exercise test can predict cardiovascular alterations in Hodgkin Lymphoma (HL) Survivors. In addition, to study the effects of exercise training on physical capacity and cardiovascular responses in these patients.

Conditions

• Hodgkin Lymphoma, Adult
• Cardiovascular Diseases
• Radiation Effect
• Chemotherapy Effect

Interventions

PROCEDURE

Physical Characteristics

Body Weight, Height

DIAGNOSTIC_TEST

Assessment of Heart rate variability

Holter 24h

DIAGNOSTIC_TEST

Blood Pressure and Cardiac Autonomic Control

Non-invasive photoplethysmography (Finometer® PRO) monitored by the electrocardiogram and respiratory frequency by a piezoelectric chest strap.

DIAGNOSTIC_TEST

Evaluation of Baroreflex Control

The magnitude and latency of the baroreflex control of the heart rate will be assessed by bivariate analysis using the autoregressive method.

DIAGNOSTIC_TEST

Cardiac Function and Structure

Echocardiogram

DIAGNOSTIC_TEST

Assessment of Coronary Anatomy and Calcium Score

Angiotomography

DIAGNOSTIC_TEST

Blood Assessments

Serum and Plasma will be extracted by centrifugation. NT-pro BNP (Roche™) and c-TnI (imunoassay Elecys 2010).

DIAGNOSTIC_TEST

Physical Capacity

Cardiopulmonary Exercise Test.

PROCEDURE

Physical Training

Aerobic exercise: 48 sessions of 60 minutes: 5 minutes of warm-up, 40 minutes of exercise. Resistance exercise: 10 minutes of exercise and 5 minutes of recovery.

Sponsors & Collaborators

• University of Sao Paulo General Hospital

  lead OTHER

Principal Investigators

• Carlos E Negrao, PhD · Instituto do Coracao, HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Model

FACTORIAL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-10-21

Primary Completion

2022-10-21

Completion

2023-10-21

Countries

• Brazil

Study Locations