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OSA as a Remote Ischemic Preconditioning in Vascular Surgery

NCT04630535 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2026-04-27

No results posted yet for this study

Summary

Ischemia and reperfusion (I/R) injury during abdominal aortic aneurysm (AAA) repair is inevitable and may lead to postoperative multi-organ failure. Remote ischemic preconditioning (short periods of ischemia in anticipation of longer period of ischemia) may act protectively against ischemia.

Studies of ischemic preconditioning in patients with AAA are conflicting. Obstructive sleep apnea (OSA) is a sleep disordered breathing syndrome which may have a protective effect against ischemia.

The investigators hypothesize that I/R injury will be less pronounced in patients who have OSA and that the extent of I/R injury will inversely correlate with OSA severity. Accordingly, the aim of this study is to compare postoperative complications and markers of I/R in patients undergoing elective AAA repair who do and do not have OSA.

Conditions

Interventions

PROCEDURE

aorto-bifemoral bypass surgery

aorto-bifemoral bypass surgery (Leriche syndrom, elective AAA repair)

Sponsors & Collaborators

  • Masaryk University

    collaborator OTHER

  • St. Anne's University Hospital Brno, Czech Republic

    lead OTHER

Principal Investigators

  • Ivan Cundrle, M.D., Ph.D. · St. Anne's University Hospital in Brno

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-11-01
Primary Completion
2028-12-31
Completion
2029-01-31

Countries

  • Czechia

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04630535 on ClinicalTrials.gov