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Effects of L-arginine on Myocardial Energetic Efficiency and Global Longitudinal Strain

NCT04626375 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 54

Last updated 2022-07-27

No results posted yet for this study

Summary

The study is designed to evaluate the effects of L-arginine on myocardial structure and function and circulating microRNAs in patients with arterial hypertension.

The study will analyze the impact of 4 weeks treatment randomized to L-arginine or placebo, on mechanical-energy efficiency (MEE) and longitudinal strain in patients with arterial hypertension. The investigators will also assess whether the changes in MEE and strain induced by L-arginine treatment is associated with changes in circulating micro RNAs.

Conditions

  • Myocardial Dysfunction

Interventions

DRUG

Bioarginine

In the Bioarginine group the partecipants take bioarginine (2 vials per os of 1.66 g every 12 hours) for 4 week

DRUG

Placebo oral tablet

In the Placebo group the participants take bio-arginine (2 vials per os of 1.66 g every 12 hours) for 4 week

Sponsors & Collaborators

  • Prof. Raffaele Izzo

    collaborator UNKNOWN

  • Prof. Costantino Mancusi

    collaborator UNKNOWN

  • Federico II University

    lead OTHER

Principal Investigators

  • Bruno Trimarco, MF · Federico II University, DPT of Advanced Biomedical Sciences

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-09-14
Primary Completion
2021-08-01
Completion
2021-08-30

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04626375 on ClinicalTrials.gov