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Personalized Treatment for Patients With Premature Ventricular Beats

NCT04617717 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 224

Last updated 2023-11-02

No results posted yet for this study

Summary

Frequent premature ventricular beats (PVBs) are common, negatively affects the quality of life for many patients, and can lead to impaired contractile function. Rule-out of structural heart disease is key in the assessment of PVBs. Cardiac MR has a high sensitivity for structural heart disease, but the diagnostic gain from this resource-demanding procedure in the work-up of patients with PVBs is unknown. There is a need to establish the role of MR in the evaluation of patients with PVBs to improve diagnostic efficacy, establish treatment strategies, and promote further research. This project will answer three key questions: 1) What is the diagnostic gain from cardiac MR in patients with PVBs? 2) Is MR the real gold standard to rule-out structural heart disease in patients with PVBs? 3) Can non-invasive heart rate parameters guide the strategy for induction of PVBs during invasive electrophysiological procedures?

Conditions

  • Ventricular Premature Complexes

Interventions

PROCEDURE

Invasive cardiac electrophysiological study and ablation therapy

Invasive cardiac electrophysiological study with cathecholamine provocation and pacing procedures, as well as standard 3D mapping and PVC ablation

DIAGNOSTIC_TEST

Cardiopulmonary exercise testing

Standard ergometer bicycle test

DIAGNOSTIC_TEST

Cardiac MRI

Cardiac MRI with cine-imaging and late-gadolinium enhancement

DIAGNOSTIC_TEST

Holter monitoring

24h 5 lead or 12 lead ECG recording

DIAGNOSTIC_TEST

Transthoracic echocardiography

2D echocardiography

DIAGNOSTIC_TEST

Coronary angiography

Conventional invasive coronary angiography or CT angiography as indicated

Sponsors & Collaborators

  • University of Oslo

    collaborator OTHER

  • Oslo University Hospital

    lead OTHER

Principal Investigators

  • Mathis K Stokke, MD PhD · Oslo University Hospital

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-09-30
Primary Completion
2024-06-30
Completion
2040-07-31

Countries

  • Norway

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04617717 on ClinicalTrials.gov