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Acute Exercise and NK Cell Regulation in Tissue and Circulation After IL-6R Blockade

NCT04616235 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2022-08-22

No results posted yet for this study

Summary

The study is a randomized controlled trial studying the acute effect of intense aerobic exercise upon NK (Natural Killer) cell activation and appetite-regulation in human participants with or without concommitant IL-6R receptor blockade (Tocilizumab)

Conditions

  • Interleukin-6 Inhibition
  • Physical Stress
  • Appetitive Behavior

Interventions

DRUG

Tocilizumab Injectable Product

The intervention group will undergo intense aerobic exercise with prior IL-6R infusion for 1h prior to the exercise bout.

OTHER

Saline 0.9% 100 ml NaCl 0.9% will be infused over 1 hour

The control group will undergo intense aerobic exercise with saline infusion for 1h prior to the exercise bout

Sponsors & Collaborators

  • Rigshospitalet, Denmark

    lead OTHER

Principal Investigators

  • Andreas K Ziegler, PhD · CFAS (Center For Physical Activity) Rigshospitalet

  • Jesper F Christensen, PhD · CFAS (Center For Physical Activity) Rigshospitalet

  • Claus Brandt, PhD · CFAS (Center For Physical Activity) Rigshospitalet

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-03-15
Primary Completion
2021-10-04
Completion
2021-10-04

Countries

  • Denmark

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04616235 on ClinicalTrials.gov