DC Vaccine Combined With CIK Cells in Patients With SCLC
NCT02688673 · Status: UNKNOWN · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 30
Last updated 2016-02-23
Summary
The aim of this study is to evaluate the safety and efficacy of dendritic cells (DC) combined with cytokine-induced killer (CIK) cells treatment patients with Extensive-Stage Small-Cell Lung Cancer. Experimental adopted recombinant adenovirus-code MUC1 and Survivin transfected DC, which are used for DC-based immunotherapy. Based on the results of our previously preclinical research with DC combined with CIK cells, the investigators plan to perform the clinical trial.
Conditions
- Small- Cell Lung Cancer
Interventions
- BIOLOGICAL
-
adenovirus-transfected autologous DC vaccine plus CIK cells
Sponsors & Collaborators
-
Affiliated Hospital to Academy of Military Medical Sciences
lead OTHER
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 70 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2014-08-31
- Primary Completion
- 2016-08-31
- Completion
- 2016-11-30
More Related Trials
-
DC Vaccine Therapy Combined With Cytokine-Induced Killer Cell in Treating Patients With Renal Cell Carcinoma
NCT00862303 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Clinical Efficacy and Safety of Dendritic Cytotoxic Lymphocyte(DC-CTL) Cell Infusion in NSCLC Patients
NCT02766348 ·Status: UNKNOWN ·Phase: PHASE2
-
Mature Dendritic Cell Vaccination Against Unique Immunogenic Peptides in Patients With Non Small Cell Lung Cancer (NSCLC)
NCT02419170 ·Status: WITHDRAWN ·Phase: EARLY_PHASE1
-
Anti-PD-1 Alone or Combined With Autologous Cell Therapy in Advanced NSCLC
NCT03360630 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Vaccine Therapy in Treating Patients With Stage I, Stage II, or Stage III Non-small Cell Lung Cancer
NCT00103116 ·Status: COMPLETED ·Phase: PHASE2
-
Personalized DC Vaccine for Lung Cancer
NCT02956551 ·Status: UNKNOWN ·Phase: PHASE1
-
Study of DC-CTL Combined With CIK for Advanced Solid Tumor
NCT03047525 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
DC Combined With ICIs in the Treatment of Advanced Lung Cancer Resistant to ICIs
NCT06329908 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
Clinical Study of DC-CIK Cells as a Post-remission Treatment for Malignant Tumors
NCT04292769 ·Status: UNKNOWN ·Phase: PHASE3
-
Study of DC-CIK Combined With Chemotherapy for Advanced Solid Tumor
NCT04214717 ·Status: UNKNOWN ·Phase: NA
-
Cyclin B1 Peptide-Pulsed Autologous Dendritic Cell Vaccine for Resectable Non-Small Cell Lung Cancer
NCT01398124 ·Status: WITHDRAWN ·Phase: NA
-
Denileukin Diftitox Followed by Vaccine Therapy in Treating Patients With Metastatic Cancer
NCT00128622 ·Status: COMPLETED ·Phase: PHASE1
-
DC Vaccine Therapy Combined With Cytokine-Induced Killer Cell in Treating
NCT02487550 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Neoantigen Derived DCs as Cancer Treatment
NCT05767684 ·Status: RECRUITING ·Phase: PHASE1
-
Neoantigen-expanded Autologous Immune Cell Therapy
NCT05020119 ·Status: UNKNOWN ·Phase: PHASE1
-
Impaired Immunity in Patients With Cancer: Influence of Cancer Stage, Chemotherapy, and Cytomegalovirus Infection
NCT00521287 ·Status: UNKNOWN ·Phase: PHASE2
-
Vaccination of Patients With Stage IV Melanoma With Dendritic Cells
NCT00125749 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Clinical Study of DC-AML Cells in the Treatment of Acute Myeloid Leukemia
NCT05000801 ·Status: RECRUITING ·Phase: NA
-
Dendritic Cell Vaccine for Head and Neck Cancer
NCT00492947 ·Status: WITHDRAWN ·Phase: PHASE1
-
Personalized Vaccine Generated by Autologous Dendritic Cells Pulsed With Autologous Whole Tumor Cell Lysate Treat Advanced Solid Tumor Patients With High Tumor Mutation Burden
NCT03671720 ·Status: WITHDRAWN ·Phase: EARLY_PHASE1
-
Dendritic Killer Cell-based Immunotherapy for Solid Tumors
NCT02882659 ·Status: UNKNOWN ·Phase: PHASE1
-
Anti-PD-1 Alone or Combined With Autologous DC-CIK Cell Therapy in Advanced Solid Tumors
NCT03190811 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Dendritic Cell (DC) Activated Cytokine-induced Killer Cell (DCIK) Combined With DC Treatment for Glioma
NCT01235845 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
A Study of Vaccination With Poly-ICLC and Dendritic Cells in Patients With Pancreatic Adenocarcinoma
NCT01677962 ·Status: COMPLETED ·Phase: PHASE1
-
Dendritic Cell Vaccine for Children and Adults With Sarcoma
NCT01803152 ·Status: COMPLETED ·Phase: PHASE1