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Theta Burst Stimulation Plus Habit Override Training for Compulsive Behaviors

NCT04580043 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 203

Last updated 2026-02-10

No results posted yet for this study

Summary

This project seeks to identify causal neural mechanisms underlying unwanted, repetitive behaviors (compulsions). Using non-invasive brain stimulation coupled with practice in a computer task, we will modulate activity in a target brain region and measure effects on compulsive behaviors and related measures. This work could ultimately lead to the ability to treat compulsions more effectively by targeting the regions of the brain that can help or hinder attempts to overcome compulsions.

Conditions

  • Compulsive Behavior
  • Obsessive-Compulsive Disorder

Interventions

BEHAVIORAL

Habit Override Practice

Computerized "brain training" to provide practice in overriding avoidance habits.

DEVICE

Transcranial Magnetic Stimulation

Non-invasive method for temporary, focal stimulation of brain areas. Delivered in a continuous Theta Burst Stimulation (TBS) pattern.

BEHAVIORAL

Sham Training

Computer-based task practice in a non-active/inert task.

DEVICE

Sham Transcranial Magnetic Stimulation

Sham stimulation of non-brain areas. Delivered in a continuous Theta Burst Stimulation (TBS) pattern.

Sponsors & Collaborators

  • National Institute of Mental Health (NIMH)

    collaborator NIH

  • Rebecca Price

    lead OTHER

Principal Investigators

  • Rebecca B Price, PhD · University of Pittsburgh

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-12-28
Primary Completion
2025-12-15
Completion
2025-12-15
FDA Device
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04580043 on ClinicalTrials.gov