The Norwegian Study of Nervous System Manifestations and Sequelae After COVID-19

Summary

Neurologic, neuropsychological and neuropsychiatric symptoms, signs and diagnoses are increasingly being reported in COVID-19 patients. However, the extent and implications of such "NeuroCOVID" involvement, as well as blood and MRI biomarkers for neurological and psychiatric COVID-19-affection and treatments, warrants further studies. The investigator will perform a national study with clinical and biomarker assessments of NeuroCOVID in approximately 150 Norwegian patients, recruited from ongoing COVID-studies in Norway as well as from neurological departments in Norway. The investigator will define the burden of neurological, psychological and psychiatric complications of COVID-19 disease and identify clinical characteristics and biomarkers for both short- and long-term neurological treatment and rehabilitation. Blood samples for biomarker analyses, brain MRI, clinical neurological, neurophysiological and neuropsychological assessments will be performed at 6 and 12 moths after acute disease,

Conditions

• Covid19

Interventions

OTHER

Observation

The study is a multi-center Norwegian prospective observational clinical study of the occurence of neurological, neuropsychological and psychiatric manifestations and sequelae in patients with COVID-19 at 6- and 12-months follow-up.

Sponsors & Collaborators

• University Hospital, Akershus

  collaborator OTHER

• Haukeland University Hospital

  collaborator OTHER

• Helse Stavanger HF

  collaborator OTHER_GOV

• St. Olavs Hospital

  collaborator OTHER

• University Hospital of North Norway

  collaborator OTHER

• Vestre Viken Hospital Trust

  collaborator OTHER

• Sykehuset Telemark

  collaborator OTHER_GOV

• Sykehuset Innlandet HF

  collaborator OTHER

• Ostfold Hospital Trust

  collaborator OTHER

• The Hospital of Vestfold

  collaborator OTHER

• Sorlandet Hospital HF

  collaborator OTHER_GOV

• Nordlandssykehuset HF

  collaborator OTHER

• Møre og Romsdal Hospital Trust

  collaborator OTHER

• Oslo University Hospital

  lead OTHER

Principal Investigators

• Anne Hege Aamodt, MD, PhD · Oslo University Hospital

• Hanne F Harbo, MD,PhD,Prof · Oslo University Hospital

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2020-09-01

Primary Completion

2023-05-31

Completion

2023-12-31

Countries

• Norway

Study Locations