COM701 in Combination With BMS-986207 and Nivolumab in Subjects With Advanced Solid Tumors.
NCT04570839 · Status: COMPLETED · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 48
Last updated 2024-07-18
Summary
This is a phase 1/2 open label sequential dose escalation and cohort expansion study evaluating the safety, tolerability and preliminary antitumor activity of COM701 in combination with BMS-986207 and nivolumab in patients with advanced solid tumors.
Conditions
- Endometrial Neoplasms
- Ovarian Cancer
- Solid Tumor
- Head and Neck Cancer
Interventions
- DRUG
-
COM701 in combination with BMS-986207 and nivolumab.
Study treatment with the 3 drug combination (COM701 in combination with BMS-986207 and nivolumab).
Sponsors & Collaborators
- collaborator INDUSTRY
-
Compugen Ltd
lead INDUSTRY
Principal Investigators
-
Lead COM701 ClinInfo · Compugen Ltd
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SEQUENTIAL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2020-08-31
- Primary Completion
- 2024-05-15
- Completion
- 2024-05-15
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
A Study of BMS-986488 as Monotherapy and Combination Therapy in Participants With Advanced Malignant Tumors
NCT06764771 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
A Study of BMS-986449 With and Without Nivolumab in Participants With Advanced Solid Tumors
NCT05888831 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
A Study of BMS-986249 Alone and in Combination With Nivolumab in Advanced Solid Tumors
NCT03369223 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Mirdametinib + BGB-3245 in Advanced Solid Tumors
NCT05580770 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
An Investigational Immunotherapy Study of BMS-986288 Alone and in Combination With Nivolumab in Advanced Solid Cancers
NCT03994601 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Study of BMS-986416 With and Without Nivolumab in Select Solid Tumors
NCT04943900 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of BMS-986406 as Monotherapy and Combination Therapies in Participants With Advanced Tumors
NCT05298592 ·Status: COMPLETED ·Phase: PHASE1
-
An Investigational Immunotherapy Study of BMS-986301 Alone or in Combination With Nivolumab, and Ipilimumab in Participants With Advanced Solid Cancers
NCT03956680 ·Status: COMPLETED ·Phase: PHASE1
-
An Investigational Study of BGB-58067 As a Single Agent and in Combination With Anticancer Agents in Participants With Advanced Solid Tumors
NCT06589596 ·Status: RECRUITING ·Phase: PHASE1
-
Study of BMS-986315 Alone and in Combination With Nivolumab or Cetuximab in Participants With Advanced Solid Tumors
NCT04349267 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Study to Evaluate the Safety, Tolerability, and Efficacy of BMS-986523 Alone and in Combination With Anti-Cancer Agents in Participants With Advanced Solid Malignancies
NCT07223047 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
First-In-Human Study of Monoclonal Antibody BMS-986218 by Itself and in Combination With Nivolumab in Participants With Advanced Solid Tumors
NCT03110107 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Study of NGM707 As Monotherapy and in Combination with Pembrolizumab in Advanced or Metastatic Solid Tumor Malignancies
NCT04913337 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
Tomivosertib (eFT-508) in Combination With PD-1/PD-L1 Inhibitor Therapy
NCT03616834 ·Status: COMPLETED ·Phase: PHASE2
-
Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors
NCT06293898 ·Status: RECRUITING ·Phase: PHASE1
-
A Study of BMS-986253 in Combination With Nivolumab or Nivolumab Plus Ipilimumab in Advanced Cancers
NCT03400332 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Phase 1 Study of BMS-986500 as Monotherapy or Combination Therapy in Advanced Solid Tumors
NCT06997029 ·Status: RECRUITING ·Phase: PHASE1
-
A Study of Tobemstomig + Nab-Paclitaxel Compared With Pembrolizumab + Nab-Paclitaxel in Participants With Previously Untreated, PD-L1-Positive, Locally-Advanced Unresectable or Metastatic Triple-Negative Breast Cancer
NCT05852691 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Safety Study of BMS-986016 With or Without Nivolumab in Patients With Advanced Solid Tumors
NCT02966548 ·Status: COMPLETED ·Phase: PHASE1
-
An Investigational Immuno-Therapy Study of Experimental Medication BMS-986242 Given in Combination With Nivolumab in Patients With Advanced Cancer
NCT03351231 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
A Study to Test BI 765179 Alone and in Combination With Ezabenlimab in Patients With Advanced Cancer (Solid Tumors) and BI 765179 in Combination With Pembrolizumab in Patients With Advanced Head and Neck Cancer
NCT04958239 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Liposomal Doxorubicin, Bevacizumab, and Everolimus in Patients With Locally Advanced TNBC With Tumors Predicted Insensitive to Standard Chemotherapy; A Moonshot Initiative
NCT02456857 ·Status: COMPLETED ·Phase: PHASE2
-
Study of BMS-986158 in Subjects With Select Advanced Cancers
NCT02419417 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Study of MR001 in Patients With Locally Recurrent or Metastatic Advanced Triple-Negative Breast Cancer (TNBC)
NCT07208149 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Reverse Triple Negative Immune Resistant Breast Cancer
NCT05076682 ·Status: RECRUITING ·Phase: PHASE2