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Mirtazapine Versus Dexamethasone in Preventing Postoperative Nausea and Vomiting

NCT04547842 · Status: COMPLETED · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 90

Last updated 2024-10-08

No results posted yet for this study

Summary

Mirtazapine is a noradrenergic and specific serotonergic antidepressant. Its antagonist at the 5HT3 receptor may help to prevent nausea and vomiting. The use of mirtazapine in the management of nausea and vomiting has been reported in the literature, both for treatment and premedication.

Dexamethasone, possesses analgesic, anti-inflammatory, immune-modulating, and antiemetic effects. Dexamethasone was reported to be effective in preventing nausea and vomiting in patients receiving cancer chemotherapy. It has also been shown to be effective in reducing nausea and vomiting after open and laparoscopic surgical procedures.

In this randomized controlled trial, we will compare the effectiveness of both drugs in preventing PONV in laparoscopic cholecystectomy surgery.

Conditions

  • Post Operative Nausea and Vomiting

Interventions

DRUG

Mirtazapine 30 MG

mirtazapine is given in arm M to prevent PONV

DRUG

Dexamethasone

Dexamethasone is given in arm D to prevent PONV

Sponsors & Collaborators

  • Ain Shams University

    lead OTHER

Principal Investigators

  • Rania Hussien, MD · Lecturer of Anaesthesia, Ain Shams University

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
21 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-09-01
Primary Completion
2023-07-28
Completion
2023-07-30

Countries

  • Egypt

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04547842 on ClinicalTrials.gov