Aerobic Exercise for Remyelination in Multiple Sclerosis

Summary

This is a clinical trial to determine the feasibility of a stationary aerobic cycling intervention and explore if aerobic exercise independently promotes remyelination in people with multiple sclerosis (MS).

Conditions

• Multiple Sclerosis
• Sclerosis
• Demyelinating Diseases
• Autoimmune Diseases of the Nervous System
• Nervous System Diseases
• Demyelinating Autoimmune Diseases, CNS
• Exercise

Interventions

BEHAVIORAL

Aerobic exercise

Aerobic exercise performed on a stationary ergometer for 30 minutes, thrice weekly, with graded supervision. Participants will participate in the intervention over 24 weeks.

BEHAVIORAL

Education Group Control

A monthly, hour-long, class over various MS topics and symptoms, led by a trained facilitator.

Sponsors & Collaborators

• Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

  collaborator NIH

• Portland VA Medical Center

  collaborator FED

• Oregon Clinical and Translational Research Institute

  collaborator OTHER

• Myelin Repair Foundation

  collaborator UNKNOWN

• EMD Serono

  collaborator INDUSTRY

• Medical Research Foundation, Oregon

  collaborator OTHER

• Oregon Health and Science University

  lead OTHER

Principal Investigators

• Lindsey B Wooliscroft, MD · Oregon Health and Science University

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

64 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2021-04-29

Primary Completion

2025-03-27

Completion

2025-03-27

Countries

• United States

Study Locations