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Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry

NCT04536103 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 88

Last updated 2026-02-27

No results posted yet for this study

Summary

Currently the diagnosis of OA is based on radiographs and clinical findings, which is limited to detecting late-stage disease. There is a pressing, unmet clinical need for robust assessment of early changes in cartilage health. Towards this goal, extensive efforts are ongoing to develop quantitative MRI for cartilage matrix analysis. MR T1ρ and T2 relaxation times have shown to be promising imaging biomarkers for early cartilage degeneration and prediction of disease progression. However, many challenges remain to clinically applying these techniques, including lack of standardized acquisition and quantification methods, and long acquisition times. The study aims to develop novel, fast and reproducible MR T1ρ and T2 relaxation time imaging methods on MR systems from multiple vendors and establish a platform for standardization and cross validation of these measures as a tool for clinical trials using such techniques. Following method validation, patients at risk for osteoarthritis will be tested.

Conditions

  • Bone Diseases, Infectious
  • Musculoskeletal Diseases
  • Joint Diseases
  • Osteoarthritis
  • ACL Tear
  • Cartilage Degeneration

Interventions

DIAGNOSTIC_TEST

MRI

Observational Study of novel MR imaging and image processing techniques that will provide reliable and fully quantitative evaluation of inflammation, chronic structural changes and vascularity in healthy patients and patients with ACL injury.

Sponsors & Collaborators

  • Xiaojuan Li

    lead OTHER

Principal Investigators

  • Xiaojuan Li · Director, Program for Advanced Musculoskeletal Imaging

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-04-01
Primary Completion
2026-02-24
Completion
2026-12-28

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04536103 on ClinicalTrials.gov