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Intraoperative Lidocaine and Combined With Ketamine on Opioid After Bariatric Surgery

NCT04524130 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 87

Last updated 2025-05-09

No results posted yet for this study

Summary

The most effective long-term treatment for obesity is bariatric surgery, however, postoperative pain control is challenging in these group of population. Opioid-sparing technique with multimodal analgesia is recommended but the evidence supported is still limited. Multimodal analgesia, particularly lidocaine and ketamine, has been used effectively in various type of surgery. However, the evidence supported their use in obese patients undergoing bariatric surgery is limited.

Conditions

  • Laparoscopic Bariatric Surgery

Interventions

DRUG

Lidocaine Hydrochloride

lidocaine will be given 1.5 mg/kg bolus at induction then 2mg/kg/hr until the end of surgery.

DRUG

Ketamine

Ketamine will be given 0.35 mg/kg bolus at induction then 0.2 mg/kg/hr until the end of surgery.

DRUG

Placebo

Normal saline will be given with the same rate of lidocaine or ketamine.

Sponsors & Collaborators

  • Mahidol University

    lead OTHER

Principal Investigators

  • Parichat Tovikkai · Mahidol University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-04-01
Primary Completion
2024-10-30
Completion
2025-01-31

Countries

  • Thailand

Study Locations

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Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04524130 on ClinicalTrials.gov