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Neuroinflammation in Cognitive Decline Post-cardiac Surgery

NCT04520802 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 15

Last updated 2023-03-31

No results posted yet for this study

Summary

Major cardiovascular surgery is associated with postoperative cognitive decline (POCD), with a deterioration in memory, attention and speed of information processing. A multifactorial pathophysiology is presumed but this study focuses on the role of (neuro)inflammation in the development of POCD after coronary artery bypass grafting (CABG) surgery.

Conditions

Interventions

DIAGNOSTIC_TEST

18F-DPA-714 PET/CT neuroimaging

* Pre- and postoperative neuroimaging using 18F-DPA-714 PET/CT and brain MRI. * Longitudinal neuropsychological examinations (up to 6 months postoperatively) * Blood samples are drawn to assess the severity of the systemic inflammatory response

Sponsors & Collaborators

  • Radboud University Medical Center

    lead OTHER

Principal Investigators

  • Wilson F Abdo, MD PhD · Radboud University Medical Center

Eligibility

Min Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-02-18
Primary Completion
2022-07-01
Completion
2022-07-01

Countries

  • Netherlands

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04520802 on ClinicalTrials.gov