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Gut Organoid and Microbiome Interactions in Hypertension

NCT04497727 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 35

Last updated 2025-09-29

Study results available
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Summary

The study compared basic properties of gut epithelia of hypertensive and normotensive reference subjects. The study determined if there are fundamental differences in the gut epithelium in hypertension compared to normotension. Specifically, this study examined gene expression profiles of gut organoids derived from biopsy samples of hypertensive and normotensive individuals undergoing clinically indicated colonoscopy.

Conditions

Interventions

OTHER

Gene Expression

Gene expression analysis of biopsy specimens obtained during routine colonoscopy examination

Sponsors & Collaborators

  • University of Florida

    lead OTHER

  • National Heart, Lung, and Blood Institute (NHLBI)

    collaborator NIH

Principal Investigators

  • Carl Pepine · University of Florida

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-03-05
Primary Completion
2022-04-08
Completion
2024-04-21

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04497727 on ClinicalTrials.gov