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Genetics and Epigenetics of Graves' Orbitopathy

NCT04488406 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 12

Last updated 2020-07-28

No results posted yet for this study

Summary

Graves' orbitopathy (GO) is an autoimmune disease persisting when immunosuppression is achieved. Orbital fibroblasts from GO patients display peculiar phenotypes even if not exposed to autoimmunity, possibly reflecting genetic or epigenetic mechanisms, to be investigated here.

Primary cultures of orbital fibroblasts from GO and control patients will be established. Cell proliferation, release of hyaluronic acid (HA) and HA synthases (HAS) will be measured. Next Generation Sequencing and gene expression analysis of the whole genome will be performed, as well as global DNA methylation assay.

Conditions

  • Graves Ophthalmopathy

Interventions

OTHER

No Intervention

Not applicable to these subjects. There is no study-related intervention

Sponsors & Collaborators

  • University of Pisa

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-01-01
Primary Completion
2020-03-31
Completion
2020-03-31

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04488406 on ClinicalTrials.gov