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Nano-X Image Guidance: CBCT With Gravity-induced Motion

NCT04488224 · Status: WITHDRAWN · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL

Last updated 2026-05-19

No results posted yet for this study

Summary

A pilot stage, device feasibility trial, to investigate the feasibility of acquiring cone beam computed tomography (CBCT) images for image guidance for radiation therapy by maintaining a fixed imaging system and rotating the participant about the horizontal axis using the Nano-X patient rotation system. It is a single-arm, controlled, single-blinded, non-treatment, non-invasive, single-institution trial.

Conditions

Interventions

DEVICE

Nano-X Patient Rotation System

The Nano-X prototype is a horizontal patient rotation system that immobilises participants while being rotated on the horizontal axis. This device will be used to rotate patients horizontally while cone-beam Computed Tomography (CBCT) projections are acquired.

RADIATION

Conventional CBCT scan

A conventional cone-beam Computed Tomography (CBCT) scan is acquired on standard radiotherapy machinery.

OTHER

Psychometrically validated questionnaires

The Claustrophobia Questionnaire (CLQ), Short Form State/Trait Anxiety inventory (STAI) and Fast Motion Sickness (FMS) questionnaires administered. CLQ only once before the first session, STAI and FMS both before and after each Nano-X CBCT session.

Sponsors & Collaborators

  • South Eastern Sydney Local Health District

    collaborator OTHER_GOV

  • University of Sydney

    lead OTHER

Principal Investigators

  • Paul J Keall, PhD · ACRF Image X Institute, University of Sydney

  • Michael Jackson, MD · Prince of Wales Hospital

  • Simon Downes, MASc · Prince of Wales Hospital

  • Mark Gardner, PhD · ACRF Image X Institute, University of Sydney

Study Design

Allocation
NON_RANDOMIZED
Purpose
DEVICE_FEASIBILITY
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-09-01
Primary Completion
2025-12-11
Completion
2025-12-11

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04488224 on ClinicalTrials.gov