Influence of Military Preventive Policy for reCruit Training on COVID-19 Seroconversion

Summary

This study is intended to address the association between vitamin D status and seroconversion to SARS-CoV-2 in healthy young adults.

The primary aim of the study is to determine the rates of 'silent' seroconversion rates, consistent with asymptomatic transmission of SARS-CoV-2, in a young healthy adult population with a wide spread of vitamin D concentrations.

The secondary aims of this study are to explore:

1. Any effect of vitamin D status on symptomatic illness.
2. The background 'point' prevalence and subsequent rate of increase in seropositivity for SARS-CoV-2 in healthy young adults.
3. The individual reductions in seropositivity to SARS-CoV-2 over time, and changes in seropositivity in a defined young adult population over time.
4. Where salivary Immunoglobulin A (IgA) may be used to provide an alternative/ complementary serological method
5. The effect (if any) of vitamin D supplementation on seroconversion rates stratified by: i) level of baseline vitamin D 'deficiency/ insufficiency/ sufficiency' status; ii) extent of BMI-defined normal/overweight/obesity cut-offs and iii) gender.

Conditions

• SARS-CoV Infection
• Vitamin D Deficiency
• Covid19
• Acute Respiratory Tract Infection

Interventions

DIETARY_SUPPLEMENT

Vitamin D

Pure Encapsulations' manufacturing facility is a US Food and Drug Administration (FDA) inspected and NSF International Good Manufacturing Practices registered company.

Sponsors & Collaborators

• Leeds Beckett University

  collaborator OTHER

• Liverpool John Moores University

  collaborator OTHER

• Royal Centre for Defence Medicine

  lead OTHER_GOV

Principal Investigators

• David R Woods, MD · Royal Centre of Defence Medicine, Birmingham, UK

• Julie P Greeves, PhD · Army Health and Performance Research, Andover, UK

• Neil Walsh, PhD · Liverpool John Moores University

Study Design

Allocation

NON_RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

30 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2020-09-01

Primary Completion

2021-04-28

Completion

2021-04-28

Countries

• United Kingdom

Study Locations