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Influence of Hypoxic Induced Factors in Patients With Hereditary Hemorrhagic Telangiectasia

NCT04469517 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2024-12-06

No results posted yet for this study

Summary

Patients with hereditary hemorrhagic telangiectasia (HHT) suffer from an inherited disorder leading to systemic vascular malformations. Mutations in several genes of the transforming growth factor (TGF)-β superfamily pathway influence angiogenesis in patients with HHT. The genetic loss of ALK1 or ENG alone are not sufficient to induce AVMs; environmental insults that could trigger angiogenesis (e.g. wounding) are also needed. In this study it will be analyzed if hypoxic induced factors could have an influence on the disease HHT.

Conditions

  • Hereditary Hemorrhagic Telangiectasia

Interventions

OTHER

hypoxic induced factors

hypoxic induced factors analyzed in blood sample

Sponsors & Collaborators

  • University Hospital, Essen

    lead OTHER

Principal Investigators

  • Freya Droege, MD · University hospital Essen Otorhinolaryngology, Hufelandstr. 55, 45147 Essen, Germany

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-08-10
Primary Completion
2025-12-31
Completion
2026-10-01

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04469517 on ClinicalTrials.gov