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Proton Versus Photon Therapy in Anal Squamous Cell Carcinoma

NCT04462042 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2025-04-03

No results posted yet for this study

Summary

Dosimetric studies suggest that radiotherapy with protons has a potential to reduce side effects compared to treatment with photons for patients with anal carcinoma (AC). There are so far no studies comparing these treatment techniques in a randomised setting. The aim of this study is to compare side effects following photon therapy versus proton therapy within the framework of a randomised controlled trial.

Conditions

  • Anal Cancer Squamous Cell

Interventions

RADIATION

Proton radiotherapy

Proton radiotherapy

RADIATION

Photon radiotherapy

Conventional photon radiotherapy

Sponsors & Collaborators

  • Region Västerbotten

    collaborator OTHER_GOV

  • Uppsala County Council, Sweden

    collaborator OTHER_GOV

  • Umeå University

    lead OTHER

Principal Investigators

  • Nina Cavalli Björkman, MD · Uppsala University Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-04-07
Primary Completion
2026-04-01
Completion
2031-03-28

Countries

  • Sweden

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04462042 on ClinicalTrials.gov