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Assessment of Preload Responsiveness in ARDS Patients During Prone Position

NCT04457739 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 58

Last updated 2022-03-02

No results posted yet for this study

Summary

Evaluation of preload responsiveness in ARDS patients during prone position is difficult and only one study showed Trendelenburg manoeuvre can be used in this group of patients. This study aims to investigate whether end-expiratory occlusion test, tidal volume challenge (using the changes in PPV) can be used to evaluate preload responsiveness in patients with ARDS ventilated with a low tidal volume and who underwent a PP session.

Conditions

  • Acute Respiratory Distress Syndrome
  • Septic Shock
  • Hemodynamic Instability

Interventions

OTHER

Tidal volume challenge

Increasing tidal volume from 6 to 8 mL/kg during 1 min

OTHER

End-expiratory occlusion test

Interrupting the ventilator at end-expiration for 15-30 s and assessing the resulting changes in cardiac output

OTHER

Trendelenburg maneuver

Patients remained in prone position with a 13° upward bed angulation throughout the study and then be positioned in a declining position at -12 ° for 1 minute

Sponsors & Collaborators

  • Bicetre Hospital

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-01-08
Primary Completion
2021-05-06
Completion
2021-12-31

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04457739 on ClinicalTrials.gov