A Clinical Study of Exploring Camrelizumab in the Treatment of Colorectal Mucinous Adenocarcinoma(MAC)
NCT04446091 · Status: UNKNOWN · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 40
Last updated 2020-06-24
Summary
This is an open-label, single center, non-randomized, phase Ⅱ trial to evaluate safety and efficacy of using the combination treatment of Camrelizumab with anti-angiogenic drugs and Chemotherapy of metastatic colorectal mucinous adenocarcinoma(MAC).
Conditions
Interventions
- DRUG
-
Carilizumab + anti-angiogenic TKIs (available with fuquitinib, rigofenib, apatinib, etc.)
Observe the efficacy of immune checkpoint inhibitors combined with anti-angiogenic drugs for colorectal mucinous adenocarcinoma
- DRUG
-
Carilizumab + anti-angiogenic TKIs (available with fuquitinib, rigofenib, apatinib, etc.)+Irinotecan
Observe the efficacy of immune checkpoint inhibitors combined with anti-angiogenic drugs and chemotherapy for colorectal mucinous adenocarcinoma
Sponsors & Collaborators
-
Zhejiang Cancer Hospital
lead OTHER
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- QUADRUPLE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Max Age
- 75 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2020-07-01
- Primary Completion
- 2021-07-01
- Completion
- 2022-07-01
Countries
- China
Study Locations
More Related Trials
-
SCRT Combined With Chemotherapy and Iparomlimab and Tuvonralimab in MSS or pMMR Patients With Locally Advanced Rectal Cancer
NCT06864013 ·Status: RECRUITING ·Phase: PHASE2
-
Neoadjuvant Triplet Chemotherapy Regimen in Patients With Resectable Colorectal Cancer
NCT02688023 ·Status: UNKNOWN ·Phase: PHASE2
-
A Clinical Trial Evaluating the Safety and Efficacy of Intravenous HNF4α SrRNA in Treating Metastatic CRC Patients
NCT06621173 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
The Efficacy and Safety of Neoadjuvant Therapy With Iparomlimab and Tuvonralimab in Locally Advanced MSI-H/dMMR Colorectal Cancer: An Prospective, Single-Arm Study (Neo-IT)
NCT07160647 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Localized Treatment Versus Palliative Chemotherapy in CRC Patients With 10 or More CRLM
NCT06208371 ·Status: RECRUITING ·Phase: PHASE3
-
Tislelizumab Combined With Fruquintinib and SBRT as Athird-line and Posterior Line Treatment in Patients With Advanced CRC
NCT04924179 ·Status: UNKNOWN ·Phase: PHASE2
-
Treatment of Rectal Cancer With Long-term Concurrent Chemoradiotherapy Combined With Camrelizumab
NCT06304545 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Efficacy of Combination Immunotherapy in Patients With Metastatic Colorectal Cancer
NCT05414461 ·Status: COMPLETED ·Phase: PHASE2
-
Postoperative Chemotherapy With/Without Radiotherapy and Immunotherapy for Colorectal Liver Metastases With High Risk of Locally Recurrence
NCT06120127 ·Status: RECRUITING ·Phase: PHASE2
-
Efficacy and Safety Study of DC-CIK Cell Therapy Combined With Epaloliposide, Vortexil, and Regorafenib as Third-line Treatment for Advanced Colorectal Cancer.
NCT07343791 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
A Trial of Neoadjuvant mFOLFOXIRI Versus CRT in the EMVI Positive LARC
NCT04423965 ·Status: UNKNOWN ·Phase: PHASE2
-
Preoperative Short Course Radiotherapy With Chemotherapy and Camerelizumab in Locally Advanced Rectal Cancer
NCT04231552 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Involve-site Radiotherapy Combined With Chemotherapy and Immunotherapy as Neoadjuvant Treatment for Locally Advanced Rectal Cancer
NCT07161115 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Neoadjuvant Treatment With mFOLFOXIRI Plus Cadonilimab (AK104) Versus mFOLFOX6 in Locally Advanced Colorectal Cancer
NCT05571644 ·Status: RECRUITING ·Phase: PHASE2
-
Neoadjuvant Moderately Hypofractionated Radiotherapy Combined with Chemotherapy and Immunotherapy for High-risk LARC
NCT06599827 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Consolidative Radiotherapy Plus Maintenance Chemotherapy for Metastatic Colorectal Cancer
NCT03142282 ·Status: UNKNOWN ·Phase: PHASE2
-
A Prospective Phase II Randomized Clinical Trial of Preoperative Chemotherapy Combined With Short-course Radiotherapy Versus Conventional Neo-adjuvant Therapy for Locally Advanced Rectal Cancer Implemented by MDT
NCT02941562 ·Status: UNKNOWN ·Phase: PHASE2
-
Radiotherapy With Neoadjuvant Chemotherapy and Immunotherapy in Rectal Cancer
NCT04558684 ·Status: SUSPENDED ·Phase: PHASE1/PHASE2
-
SCRT Followed by Camrelizumab Combined With Fluzoparib and Chemotherapy as Neoadjuvant Therapy for LARC
NCT06516445 ·Status: RECRUITING ·Phase: PHASE2
-
Ivonescimab Plus Chemotherapy in Patients With Initially Unresectable Colorectal Cancer Liver Metastases
NCT06848842 ·Status: RECRUITING ·Phase: PHASE2
-
The Safety and Efficiency of Stent-based Diverting Technique Versus Ileostomy in Rectal Cancer Patients
NCT06204497 ·Status: COMPLETED ·Phase: NA
-
Exploratory Clinical Study of Claudin18.2-Targeted CAR-DC and CAR-T Therapy in Advanced Colorectal Cancer
NCT06946615 ·Status: RECRUITING ·Phase: PHASE1
-
Neoadjuvant mFOLFOXIRI Plus Bevacizumab in Patients With High-Risk Locally Advanced Rectal Cancer
NCT04215731 ·Status: RECRUITING ·Phase: PHASE3
-
A Real-world Study of Chidamide in Combination with PD-1/PD-L1 Antibodies and Anti-angiogenic Agents in Advanced MSS Colorectal Cancer
NCT06682247 ·Status: NOT_YET_RECRUITING
-
A Study of Radiotherapy Combined With Raltitrexed and Irinotecan in Metastatic or Locally Recurrent Colorectal Cancer
NCT04499586 ·Status: UNKNOWN ·Phase: PHASE2