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Autophagy/Apoptosis Balance During Pregnancy

NCT04443660 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 97

Last updated 2025-12-31

No results posted yet for this study

Summary

The object of this study is to assess the intra- and inter-individual variability of apoptosis and autophagy activities in women during pregnancy: 1 / in women with a normal pregnancy and 2 / in pregnant women particularly at risk of complications.

The study investigators hypothesize that there would be an intra-trophoblastic dialogue between the mechanisms of autophagy and apoptosis, the promotion of one partially inhibiting the other. The increase in trophoblastic autophagy during pregnancy could thus constitute an anti-apoptosis defense phenomenon, the exhaustion of which would lead to cellular apoptosis and to pathogenic consequences when it devastates the syncytiotrophoblast.

Conditions

  • Pregnancy Related

Interventions

OTHER

Blood test

Blood samples taken to test levels of autophagy and apoptosis

Sponsors & Collaborators

  • Centre Hospitalier Universitaire de Nīmes

    lead OTHER

Principal Investigators

  • Sylvie Bouvier · CHU Nimes

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-12-30
Primary Completion
2024-09-30
Completion
2025-04-07

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04443660 on ClinicalTrials.gov