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Opioid-Free Anesthesia for Patients With Joint Hypermobility Syndrome Undergoing Craneo-Cervical Fixation: A Case-series

NCT04437589 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 42

Last updated 2020-07-10

No results posted yet for this study

Summary

Cranio-cervical instability (CCI) has been well identified in diseases regarding connective tissue, such as Ehlers-Danlos Syndrome/Hipermobility Type (EDS-HT). These patients frequently suffer from severe widespread pain with very difficult management and control. Chronic neuroinflamation, opioid-induced hyperalgesia, and central sensitization phenomena may explain this complex painful condition. A retrospective, observational, consecutive case series study is designed to determine if opioid-free anesthetic management shows a reduction in postoperative pain and opioid rescues needs in comparison with opioid-based anesthesia management for patients with EDS-HT undergoing crano-cervical fixation.

Conditions

  • Ehlers-Danlos Syndrome
  • Craniocervical Syndrome

Sponsors & Collaborators

  • Servei Central d'Anestesiologia

    lead OTHER

Principal Investigators

  • Carlos Rafael Ramirez Paesano, MD · Servei d'Anestesiologia Centro Médico Teknon

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-09-06
Primary Completion
2020-03-09
Completion
2020-03-09

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04437589 on ClinicalTrials.gov