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Cerebral Compliance Impairment in COVID-19

NCT04429477 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2020-09-22

No results posted yet for this study

Summary

Several recent studies point to the possibility of the new coronavirus (SARS-Cov2), which currently causes pandemic COVID-19, to infiltrate the central nervous system (CNS) and cause primary damage to neural tissues, increasing the morbidity and mortality of these patients. A pathophysiological hypothesis for insulting the CNS would be the impairment of cerebral compliance (CC), because elevation of intracranial pressure (ICP), but due to the invasive nature of the methods available for ICP evaluation, this hypothesis has so far not been verified. Recently, a noninvasive technique was developed to evaluate CC (B4C sensor), making it possible to analyse CC in patients outside the neurosurgical environment. Therefore, the main objective of this study was to assess the presence of CC impairment in patients with COVID-19, and observe potential influences of this syndrome on cerebral hemodynamics.

Conditions

  • Intracranial Hypertension
  • Cerebral Circulatory Failure

Interventions

DEVICE

Cerebral compliance and hemodynamics monitoring

Noninvasive devices are been used to assess cerebral circulation and compliance.

Sponsors & Collaborators

  • University of Sao Paulo

    lead OTHER

Eligibility

Min Age
1 Year
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-05-01
Primary Completion
2020-07-15
Completion
2020-07-31
FDA Device
Yes

Countries

  • Brazil

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04429477 on ClinicalTrials.gov