Bevacizumab Combined With Gefitinib in the Treatment of Advanced NSCLC
NCT04425187 · Status: UNKNOWN · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 120
Last updated 2020-06-12
Summary
To compare the efficacy and safety of gefitinib combined with bevacizumab and gefitinib in the treatment of L858R positive mutation in exon 21 of EGFR gene in advanced NSCLC.
Conditions
- PFS
Interventions
- DRUG
-
Gefitinib
gefitinib 250mg (1 tablet), once a day,PO
- DRUG
-
Bevacizumab Combined With Gefitinib
Bevacizumab Combined With Gefitinib
Sponsors & Collaborators
-
Fudan University
lead OTHER
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2020-06-08
- Primary Completion
- 2021-12-31
- Completion
- 2022-12-31
Countries
- China
Study Locations
More Related Trials
-
High-dose Furmonertinib Combined With Bevacizumab and Intrathecal Pemetrexed Chemotherapy in Patients With EGFR-mutated Non-small Cell Lung Cancer and Meningeal Metastasis
NCT06812871 ·Status: COMPLETED ·Phase: PHASE2
-
Neoadjuvant Befotertinib Combined Bevacizumab or Platinum-based Double Chemotherapy for Resectable Locally-advanced EGFR Mutation-positive Non-Small Cell Lung Cancer
NCT06755684 ·Status: RECRUITING ·Phase: PHASE2
-
A Study to Predict Gefitinib' s Efficacy for Lung Cancer by Plasma Free Nucleic Acids EGFR Gene Mutation Test
NCT02738684 ·Status: UNKNOWN
-
Phase II Study of Afatinib Plus Bevacizumab in the Treatment Epidermal Growth Factor Receptor (EGFR) Exon G719X, S768I, and L861Q Mutation Metastatic Non-Small Cell Lung Cancer
NCT05267288 ·Status: UNKNOWN ·Phase: PHASE2
-
Efficacy and Safety Study of Bevacizumab Plus Chemotherapy in EGFR-TKI Resistant Non-Squamous Non-Small Cell Lung Cancer
NCT02139579 ·Status: UNKNOWN ·Phase: PHASE2
-
Osimertinib Combined With Bevacizumab in the Treatment Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertions Metastatic Non-Small Cell Lung Cancer
NCT04974879 ·Status: UNKNOWN ·Phase: PHASE2
-
Befotertinib Adjuvant Therapy in Stage IA2-IB NSCLC Patients
NCT06561620 ·Status: RECRUITING ·Phase: PHASE4
-
Osimertinib With Bevacizumab for Leptomeningeal Metastasis From EGFR-mutation Non-Small Cell Lung Cancer
NCT04425681 ·Status: UNKNOWN ·Phase: PHASE2
-
Bevacizumab Plus EGFR-TKIs in Chinese Patients With EGFR-mutant NSCLC: a Real-world Study
NCT04575415 ·Status: UNKNOWN
-
A Study of Gefitinib With or Without Apatinib in Patients With Advanced Non-squamous Non-Small-Cell Lung Cancer Harboring EGFR Mutations
NCT02824458 ·Status: UNKNOWN ·Phase: PHASE3
-
Evaluation of the Efficacy and Safety of Furmonertinib Combined with Bevacizumab As First-Line Treatment for EGFR-Positive Non-Small Cell Lung Cancer with Brain Metastases: a Single-Arm, Open-Label, Prospective Phase II Clinical Study
NCT06728865 ·Status: RECRUITING ·Phase: PHASE2
-
A Clinical Study on the Efficacy and Safety of the Combination of Limertinib and Bevacizumab Versus Limertinib as First-line Treatment for NSCLC.
NCT06982924 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
High-Dose Firmonertinib Plus Bevacizumab as Neoadjuvant Therapy for Resectable EGFRm Stage II-IIIB NSCLC
NCT07182708 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Cisplatin and Gemcitabine With or Without Bevacizumab in EGFR Wild-type Non-Small Cell Lung Cancer
NCT01623102 ·Status: UNKNOWN ·Phase: PHASE2
-
Neoadjuvant Furmonertinib Plus Bevacizumab or Furmonertinib Monotherapy for Resectable and Potentially Resectable Stage III-IVA EGFR Mutation-Positive Lung Adenocarcinoma
NCT05503667 ·Status: RECRUITING ·Phase: PHASE2
-
Gefitinib With Chemotherapy or Anti-angiogenesis in NSCLC Patients With Bim Deletion or Low EGFR Mutation Abundance
NCT03267654 ·Status: UNKNOWN ·Phase: PHASE2
-
Befotertinib and Icotinib for NSCLC With Uncommon EGFR Mutations
NCT06517953 ·Status: RECRUITING ·Phase: PHASE2
-
Sunvozertinib Treatment in Untreated Advanced NSCLC With EGFR Uncommon Mutations
NCT07117890 ·Status: RECRUITING ·Phase: PHASE2
-
Real-world Study of Sunvozertinib Treatment in Advanced EGFR-Mutant NSCLC After EGFR-TKI Treatment Failure
NCT06786208 ·Status: NOT_YET_RECRUITING
-
Compare Bevacizumab in Combination With Erlotinib Versus Erlotinib Alone in NSCLC Patients Activating EGFR Mutations
NCT02759614 ·Status: COMPLETED ·Phase: PHASE3
-
Study of MCLA-129 Combined With Befotertinib in the Treatment of Advanced Non-small Cell Lung Cancer With EGFR Sensitive Mutation
NCT06015568 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1
-
Osimertinib and Bevacizumab as Treatment for EGFR-mutant Lung Cancers
NCT02803203 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Intrathecal Pemetrexed Combined With High-dose Furmonertinib and Beva for EGFR-m NSCLC With Leptomeningeal Metastases
NCT06537297 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Study to Assess Safety/Tolerability/Efficacy of Gefitinib Versus Docetaxel in Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
NCT00536107 ·Status: TERMINATED ·Phase: PHASE4
-
A Retrospective Study About Treatment Strategy After First/Second Line EGFR-TKI Failure
NCT02618590 ·Status: UNKNOWN