MedTrace Logo

Transitional Cerebrovascular Reactivity in Very Preterm Infants

NCT04423016 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 72

Last updated 2021-07-28

No results posted yet for this study

Summary

The transitional period, defined as the first 72 hours after preterm birth, is often characterized by a significant hemodynamic instability and may also be associated with an impairment of cerebral autoregulation, with relevant clinical implications. The moving correlation coefficient between cerebral oxygenation and heart rate, also defined as TOHRx, has been previously proposed as a marker of cerebrovascular reactivity and provides an indirect estimation of cerebral autoregulation in preterm infants.

This study aims to evaluate whether different antenatal, perinatal and postnatal factors may influence cerebrovascular reactivity in very preterm infants during the transitional period.

Conditions

Interventions

DEVICE

Near Infrared Spectroscopy monitoring

Non-invasive continuous monitoring of cerebral oxygenation

DEVICE

Electrical velocimetry and pulse oximetry

Non-invasive continuous monitoring of cerebral oxygenation

Sponsors & Collaborators

  • IRCCS Azienda Ospedaliero-Universitaria di Bologna

    lead OTHER

Principal Investigators

  • Luigi Corvaglia, MD · S. Orsola-Malpighi University Hospital, Bologna, Italy

Eligibility

Min Age
1 Day
Max Age
3 Days
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-02-21
Primary Completion
2021-06-30
Completion
2021-07-03

Countries

  • Italy

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04423016 on ClinicalTrials.gov