AduLt iatrogEnic withdRawal sTudy in the ICU (ALERT-ICU)

Summary

Withdrawal from opioids and sedatives administered for medical purposes (i.e. iatrogenic withdrawal) often goes unrecognized in the critically ill, but its prevalence is high. Reports describing what is being implemented at the bedside to prevent iatrogenic withdrawal are lacking, and how patients are monitored and assessed for withdrawal has not been adequately studied. Therefore, the investigators overall objective is to determine the current analgesia and sedation weaning practices in adult ICUs. In order to accomplish this objective the investigators plan to conduct a prospective, observational, point prevalence trial. Data from this project will help support future investigation of iatrogenic withdrawal.

Conditions

• Withdrawal Syndrome
• Iatrogenic Disease

Sponsors & Collaborators

• Wilkes University

  lead OTHER

Principal Investigators

• Gilles L Fraser, PharmD, MCCM · Tufts University School of Medicine

• Scott Bolesta, PharmD, BCPS · Wilkes University

• Marc M Perreault, MSc, PharmD · Université de Montréal

• Lisa Burry, PharmD · MOUNT SINAI HOSPITAL

• Brian L Erstad, PharmD, MCCM · The University of Arizona College of Pharmacy

• Céline Gélinas, N., Ph.D. · Ingram School of Nursing

• Richard R Riker, MD, FCCM · Tufts University School of Medicine

• Katrianna D Saltarelli, Student · Wilkes University

• Jennifer Mitchell, Student · Wilkes University

• Kathryn E Smith, PharmD, BCPS, BCCCP · MaineHealth

• Federico Carini, MD · Hospital Italiano de Buenos Aires

• Rebekah Eadie, MPharm, MSc, IP, MPSNI · Ulster Hospital- South Eastern Health and Social Care Board

• Jamie Harpel, Student · Wilkes University

• Ryan Stewart, Student · Wilkes University

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2021-06-01

Primary Completion

2021-09-30

Completion

2022-04-01

Countries

• United States

Study Locations