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Tissue Microenvironment Signatures of the Mycetoma Granuloma

NCT04401969 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 28

Last updated 2020-05-26

No results posted yet for this study

Summary

Mycetoma is the most neglected of the neglected tropical diseases. It is caused by certain fungi or bacteria. It is endemic in many tropical and subtropical regions and Sudan seems to be the mycetoma homeland. This chronic subcutaneous destructive and disabling inflammatory disease has many serious medical and socio-economic impacts on patients, community and health authorities. This work may suggest new therapeutic options for mycetoma that target the inflammatory pathogenic pathway and hence help in designing universal treatment options for mycetoma patients.

Two overlapping aims were investigated in this project to advance our overall goals:

1. Profiling the immune/inflammatory signatures in the tissue microenvironment of fungus-induced mycetoma lesions
2. Profiling the immune/inflammatory signatures in the tissue microenvironment of bacteria-induced mycetoma lesions.

Conditions

  • Mycetoma

Sponsors & Collaborators

  • University of York

    collaborator OTHER

  • University of Khartoum

    lead OTHER

Principal Investigators

  • Mohamed Osman, PhD · University of Khartoum

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-03-07
Primary Completion
2019-04-16
Completion
2019-04-16

Countries

  • Sudan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04401969 on ClinicalTrials.gov