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Optimizing Cognitive Remediation

NCT04395157 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2026-02-25

Study results available
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Summary

Veterans with mental illness face challenges with community reintegration, including achieving vocational success, attaining their educational goals and going back to school, and maintaining a high quality of life. VA Mental Health Residential Rehabilitation Treatment Programs, Psychosocial Rehabilitation and Recovery Centers and other mental health treatment programs are designed to help Veterans overcome these barriers, but cognitive impairment often seen in Veterans with mental illness limits gains from these settings. Cognitive remediation interventions can be helpful, but they are either "one-size fits all," and thus may not be useful for all Veterans with mental illness, or are too narrow in scope, focusing on specific mental illnesses, limiting generalizability.

This project will test whether an objective neurophysiological biomarker, mismatch negativity (MMN), can better match the "right" Veteran to the "right" cognitive remediation treatment regardless of their specific mental health diagnosis.

Conditions

  • Schizophrenia
  • Stress Disorders, Post-Traumatic
  • Generalized Anxiety Disorder
  • Mood Disorders

Sponsors & Collaborators

  • VA Office of Research and Development

    lead FED

Principal Investigators

  • Yash B. Joshi, MD PhD · VA San Diego Healthcare System, San Diego, CA

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-12-01
Primary Completion
2025-01-01
Completion
2025-04-30

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04395157 on ClinicalTrials.gov