VITACOV: Vitamin D Polymorphisms and Severity of COVID-19 Infection

Summary

Vitamin D deficiency has been linked to hypertension, autoimmune, infectious and cardiovascular diseases which are risk factors for COVID-19. Moreover, COVID-19 patients have a very high prevalence of hypovitaminosis D (Turin data). Taken together, we aim to investigate whether genetic variants in vitamin D-related genes contribute to a poor COVID-19 outcome, particularly in hypertension and CV patients, proposing thus a personalized therapeutics based on vitamin D supplementation in order to reduce the severity and deaths.

Conditions

• COVID-19

Interventions

OTHER

Exposure

Individuals with SARS-CoV-2 exposure and COVID-19 symptoms.

Sponsors & Collaborators

• Cardiovascular Centre of Universidade de Lisboa (CCUL)

  collaborator UNKNOWN

• Faculty of Medicine of Universidade de Lisboa (FMUL)

  collaborator UNKNOWN

• Centro Hospitalar Universitário Lisboa Norte

  collaborator OTHER

• Centro Hospitalar Universitário São João (CHUSJ)

  collaborator UNKNOWN

• CINTESIS - Center for Health Technology and Services Research

  collaborator UNKNOWN

• Universidade Nova de Lisboa

  collaborator OTHER

• HeartGenetics, Genetics and Biotechnology SA

  collaborator INDUSTRY

• Instituto Gulbenkian de Ciência (IGC)

  collaborator UNKNOWN

• University of Lisbon

  lead OTHER

Principal Investigators

• Fausto J Pinto, PhD · Faculty of Medicine of Universidade de Lisboa

• Conceição Calhau, PhD · Universidade Nova de Lisboa

• Ana Freitas, PhD · HeartGenetics SA

• Tiago Guimarães, PhD · Faculty of Medicine of the University of Porto

• Ana Melo, PhD · BioData.pt/Instituto Gulbenkian Ciência

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2020-08-01

Primary Completion

2021-01-01

Completion

2021-01-31

Countries

• Portugal

Study Locations