Chronic Fatigue Etiology and Recovery in Covid-19 Patients: the Role of Fatigability

Summary

Chronic fatigue is the most common and debilitating symptom in intensive care unit (ICU) survivors. Indeed, it has been widely reported that patients who stayed in ICU for prolonged periods report a feeling of tiredness for months to years after ICU discharge. This symptom seems particularly pronounced in Covid-19 patients and may affect their quality of life by decreasing their capacity to perform simple tasks of daily life.

The aim of the present project is to determine whether deteriorated neuromuscular function (i.e. increased fatigability) is involved in the feeling of fatigue of Covid-19 patients. Because the causes of this feeling are multi-dimensional, a large battery of tests will allow us to better understand the origin of chronic fatigue. A better knowledge of chronic fatigue etiology and its recovery will allow to optimize rehabilitation treatments to shorten the persistence of chronic fatigue and in fine improve life quality.

Conditions

• Chronic Fatigue Syndrome
• Intensive Care Unit
• Muscle

Interventions

OTHER

Questionnaires

Quality of life Depression Physical pain Social provisions Quality of sleep

BIOLOGICAL

blood test

complete blood count and cytokine concentration, TNF-alpha, LDL oxidized, AOPP, SOD, GPX, catalase, albumin, transthyretin, RBP, transferin, α-1 glycoprotein acide, ferritine, selenium, zinc, magnesium

OTHER

Maximal effort test

The maximal effort test with VO2max recordings will be assessed during the first visit to the laboratory.

DEVICE

actigraphy

assessment of sleep quality

DEVICE

Neuromuscular evaluation

* The maximum isometric force produced by the knee extensors will be measured on the ergometer * the intensity of muscular electrical activity recorded by surface electromyography * Peripheral nerve stimulation * Transcranial magnetic stimulation * Magnetic resonance imaging

OTHER

stool analysis

analyze the composition of the intestinal microbiote. concerns only the patients of Saint Etienne

OTHER

food diary

3 days of information to determine nutrient intakes. concerns only the patients of Saint Etienne

Sponsors & Collaborators

• University of Saint-Etienne

  collaborator UNKNOWN

• Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques

  collaborator OTHER

• Centre Hospitalier Universitaire de Saint Etienne

  lead OTHER

Principal Investigators

• Jérome MOREL, MD PhD · CHU de Saint Etienne

Study Design

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

35 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2020-05-27

Primary Completion

2021-08-26

Completion

2022-03-01

Countries

• France

Study Locations