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Independent and Combined Effects of Resistance Exercise Training and β-hydroxy β-methylbutyrate Plus Vitamin D

NCT03848741 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 48

Last updated 2019-07-17

No results posted yet for this study

Summary

During middle-age, humans begin to lose muscle mass and strength. With increasing age the deterioration of muscle health is associated with a decline in quality of life and the loss of independence. β-hydroxy β-methylbutyrate (HMB) plus Vitamin D (VitD) have been proposed to increase skeletal muscle mass, contractile function and improve body composition but has yet to be evaluated in middle-aged women. The overall goal of this study is to determine the effects of HMB +VitD supplementation during 12 weeks of resistance exercise training or a non-exercise control on body composition, skeletal muscle size, and skeletal muscle function in middle-aged women.

Conditions

  • Aging
  • Skeletal Muscle

Interventions

BEHAVIORAL

Non-Exercise Control

Participants will not perform structured exercise and will continue with their normal physical activity for 12-weeks.

BEHAVIORAL

Resistance Exercise Training

Participants will complete a 12-week whole-body progressive resistance exercise training program.

DIETARY_SUPPLEMENT

Placebo

Participants will be given placebo capsules to consume for 12-weeks.

DIETARY_SUPPLEMENT

HMB+VitD

Participants will be given HMB+VitD capsules to consume for 12-weeks

Sponsors & Collaborators

  • Metabolic Technologies Inc.

    collaborator INDUSTRY

  • University of Illinois at Urbana-Champaign

    lead OTHER

Principal Investigators

  • Adam Konopka, PhD · University of Illinois at Urbana-Champaign

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
45 Years
Max Age
60 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-04-01
Primary Completion
2020-12-31
Completion
2021-04-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03848741 on ClinicalTrials.gov