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Measurement of Myocardial Stiffness Using Elastometry in Patients With Aortic Stenosis

NCT04358692 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 98

Last updated 2025-09-10

No results posted yet for this study

Summary

Elastography is a new non-invasive medical technique for measuring the stiffness at a distance from a tissue. Recent advances in the development of elastography sequences for cardiac exploration suggest a more clinical approach to cardiac elastography. This study propose to compare myocardial stiffness of a group of coronary bypass patients without hypertrophic left ventricular remodeling or sequelae of myocardial infarction versus a group of patients who should benefit from a surgical aortic valve replacement for aortic stenosis.

The hypothesis is that the physiological adaptation to pressure overload constituted by aortic stenosis is responsible for a significant increase in myocardial stiffness compared to a reference group.

Conditions

  • Aortic Valve Stenosis

Interventions

DEVICE

Aixplorer Mach30

To measure myocardial stiffness by ShearWave elastography on not beating heart

Sponsors & Collaborators

  • University Hospital, Caen

    collaborator OTHER

  • University Hospital, Rouen

    lead OTHER

Principal Investigators

  • Eric Saloux, MD · University Hospital, Caen

Study Design

Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-06-30
Primary Completion
2024-06-14
Completion
2024-06-14

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04358692 on ClinicalTrials.gov